Effect of parathyroidectomy on fluctuations in calcium transport between the blood and mineralized tissues of rats.

摘要

Parathyroidectomy increases the degree of(45)Ca fluctuations between the blood and mineralized tissues (bones and teeth) in rats, which is associated with a decrease in 14C-glycine incorporation into bone proteins. Disturbances in Ca(2+)metabolism and transport during hyperparathyroidism are partly prevented by parathyroidectomy. It is mainly related to variations in the interaction of parathyroid hormone, calcitonin, 1.25(OH)2D3, and other bioactive substances, but not to initiation of mineralization with protein matrixes.