Down-regulation of protein kinase C-#alpha# detected in human colorectal cancer

摘要

The down-regulation of protein kinase C (PKC) was examined by Western blot procedure on about 30 tissue samples derived from human colorectal cancer and the corresponding normal mucosa. PKC-#alpha# down-regulation was detected in 60% of the cancer tissues compared with the respective normal mucosa and was observed in a higher frequency with the tissues under more advanced cancer stages. However, the frequencies of the down-regulation of PKC-#delta# and PKC-#zeta# were lower than that of PKC-#alpha#. These results suggest that a decreased level of PKC-#alpha# may affect the cell growth and tumor promotion in colorectal tissue.