Effects of nootropics on electrical activity in rat hippocampal CA1 area.

摘要

Experiments on rat hippocampal slices showed that high concentrations of nooglutil and mexidol, but not piracetam, suppressed the ortho- and antidromic population responses in the CA1 area evoked by paired stimulation, the orthodromic responses being more sensitive to the drugs. The effects of both drugs were blocked by AP7, a specific antagonist of N-methyl-D-aspartate receptors. It is suggested that N-activation of methyl-D-aspartate receptors by high concentrations of nooglutil and mexidol reduced CA1 pyramidal cell responsiveness.