Rapid Determination of Famoxadone and Cymoxanil in Commercial Pesticide Formulation by High Performance Liquid Chromatography Using a C18 Monolithic Rod Column

摘要

The extensive use of plant protection products in urban and rural pest control obliges to develop valid analytical methods for their successful and reliable quality control. An analytical procedure for the simultaneous determination of famoxadone and cymoxanil, by reversed phase high performance liquid chromatography based on the use of a monolithic C18 column has been developed and validated. The method involved the extraction of the active ingredients by sonication of the sample with acetonitrile and direct injection on a reversed phase liquid chromatographic system. The repeatability of the method expressed as relative standard deviation (%RSD), was lower than 1 % for both compounds. The limits of quantification for famoxadone and cymoxanil were 10 and 16 mu g mL(-1) respectively. The new method involves a considerable reduction in time for both sample preparation and analysis. The proposed analytical procedure is accurate and precise.