Palladium-catalyzed dehydrogenative β′-arylation of β-keto esters under aerobic conditions: Interplay of metal and Br?nsted acids

摘要

The Br?nsted aids: The first dehydrogenative arylation of β-keto esters with arenes under ambient aerobic conditions is described (see scheme). Under a Pd ~(II)/Br?nsted acid co-catalytic system, regioselective arylations with alkoxylated arenes and phenols were achieved in good yields, even in gram-scale conditions.