IgG/IgA pemphigus with IgG and IgA antidesmoglein 3 antibodies and IgA antidesmoglein 1 antibodies detected by enzyme-linked immunosorbent assay: a case report and review of the literature

摘要

IgA pemphigus represents a group of autoimmune blistering skin diseases characterized by intraepidermai neutrophilic pustules, intercellular IgA antibodies, or circulating IgA antibodies to keratinocyte surfaces. Currently, it is seen as a distinct subset of pemphigus with particular clinical and immunopathologic pictures. As it is a newly defined disorder, its frequency is unknown but surely rare. Even less reported is the pemphigus with deposits of both IgG and IgA on keratinocyte cell surfaces; a new entity described in the recent literature as IgG and IgA pemphigus. In this study, we report the first Tunisian case with IgG/IgA pemphigus and try to discuss the clinical and immunopathological features of this new type of pemphigus.