Recalcitrant pemphigus herpetiformis with high titer of immunoglobulin G antibody to desmoglein 1 and positive IgG antibody to desmocollin 3, elevating thymus and activation-regulated chemokine

摘要

Pemphigus herpetiformis (PH) is a rare variant of pemphigus. The most frequent antibody in PH is anti-desmoglein i (Dsgi) antibody. Whereas desmocollin i (Dsci) is recognized by immunoglobulin A (IgA) autoantibodies in subcorneal pustular dermatosis type IgA pemphigus, the presence of IgG anti-Dsc autoantibodies is still controversial, and antibodies to Dsc2 and Dsc3 have not been clearly identified. In order to accummulate data, we herein describe PH with IgG antibodies to Dsgi and DSC3. As far as we know, the only similar antibody profile in PH to have been reported is that by Kozlowska et al.