Synthesis of novel thiazolo5,4-dpyrimidines

摘要

2-Methylsulphanyl-5-aminothiazole-4-carboxamide 1 has been used as a convenient precursor for the synthesis of new thiazolo4.5-e1,2,4-triazolo4,3-cpyrimidines 5 and the corresponding tetrazolo analogue 7. A mesoionic isomer 8 seems to exist along with 7. Interesting heteroarylthiazolo pyrimidine motifs have also been prepared via suitably substituted thiazolo5,4-dpyrimidines.