Filaggrin gene loss-of-function mutations explain discordance of atopic dermatitis within dizygotic twin pairs

Thomsen Simon Francis; Elmose Camilla; Szecsi Pal Bela; Stender Steen; Kyvik Kirsten Ohm; Backer Vibeke; Thyssen Jacob Pontoppidan

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Filaggrin gene loss-of-function mutations explain discordance of atopic dermatitis within dizygotic twin pairs

机译：丝聚蛋白基因功能丧失突变解释双合子对特应性皮炎的不一致性

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ObjectivesThis study was designed to examine the association between loss-of-function mutations in the filaggrin gene (FLG) and atopic dermatitis (AD) and asthma in adult twins.

机译：目的本研究旨在检查成年双胞胎中丝蛋白基因（FLG）和特应性皮炎（AD）与哮喘的功能丧失突变之间的关系。

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来源
《International journal of dermatology》 |2016年第12期|共4页
作者
Thomsen Simon Francis; Elmose Camilla; Szecsi Pal Bela; Stender Steen; Kyvik Kirsten Ohm; Backer Vibeke; Thyssen Jacob Pontoppidan;
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正文语种 eng
中图分类皮肤病学与性病学;
关键词
atopic dermatitis; asthma; filaggrin gene loss-of-function mutations; twin study; epidemiology;

机译：特应性皮炎;哮喘;丝聚蛋白基因功能丧失突变;双胞胎研究;流行病学;

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1. Filaggrin gene loss-of-function mutations explain discordance of atopic dermatitis within dizygotic twin pairs [J] . Thomsen Simon Francis, Elmose Camilla, Szecsi Pal Bela, International journal of dermatology . 2016,第12期

机译：丝聚蛋白基因功能丧失突变解释双合子对特应性皮炎的不一致性
2. Impact of atopic dermatitis and loss-of-function mutations in the filaggrin gene on the development of occupational irritant contact dermatitis [J] . VisserM.J., LandeckL., CampbellL.E., British Journal of Dermatology . 2013,第2期

机译：特应性皮炎和丝聚蛋白基因功能丧失突变对职业性刺激性接触性皮炎发展的影响
3. Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations. [J] . Weidinger S, Illig T, Baurecht H, The Journal of Allergy and Clinical Immunology . 2006,第1期

机译：丝聚蛋白基因内功能丧失的变异易导致过敏性过敏性特应性皮炎。
4. Early Detection of Filaggrin-Related Atopic Dermatitis by Raman Spectroscopy and Principal Component Analysis [C] . Ramirez-Elias Miguel G., Gonzalez Francisco J., Alda Javier, International Conference on Raman Spectroscopy . 2010

机译：拉曼光谱和主要成分分析早期检测叶片相关的特征性皮炎
5. Filaggrin and Non-Coding Variation in Distinct Cohorts of Atopic Dermatitis [D] . Quiggle, Ashley Marie. 2016

机译：异位性皮炎不同队列中的丝蛋白和非编码变异
6. IMPACT OF ATOPIC DERMATITIS AND LOSS-OF-FUNCTION MUTATIONS IN THE FILAGGRIN GENE ON THE DEVELOPMENT OF OCCUPATIONAL IRRITANT CONTACT DERMATITIS [O] . M. J. Visser, L. Landeck, L. E. Campbell, -1

机译：异位性皮炎和丧失功能的突变进行职业刺激性接触性皮炎的聚角蛋白微丝基因对发展的影响
7. Two common loss-of-function mutations within the filaggrin gene predispose for early onset of atopic dermatitis [O] . Stemmler, Susanne, Parwez, Qumar, Petrasch-Parwez, Elisabeth, 2007

机译：丝蛋白基因内的两个常见功能丧失突变是特应性皮炎的早发诱因

Filaggrin gene loss-of-function mutations explain discordance of atopic dermatitis within dizygotic twin pairs

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