An Examination of Polygenic Score Risk Prediction in Individuals With First-Episode Psychosis

摘要

BACKGROUND: Polygenic risk scores (PRSs) have successfully summarized genome- wide effects of genetic variants in schizophrenia with significant predictive power. In a clinical sample of first- episode psychosis (FEP) patients, we estimated the ability of PRSs to discriminate case-control status and to predict the development of schizophrenia as opposed to other psychoses.