Synthesis of Polyfunctionally Substituted Fused Pyrimidine Derivatives as Antimicrobial Agents

摘要

A VARIETY of pyrimidine derivatives 2-4 and annulated pyrimidine derivatives 5-17 have been synthesized via a sequence of heterocyclization reactions of readily available 6-naphthyl - 4-oxo-2-thioxo- l,2,3,4-tetrahydroprimidine-5-carbonitrile (1) with different acidic and basic reagents. The new compounds were synthesized with the aim of studying their antimicrobial activity. The structures of all synthesized compounds were elucidated by elemental analysis and spectroscopic studies.