A break in the glomerular basement membrane in Churg-Strauss syndrome.

摘要

Breaks in the glomerular basement membrane (GBM) have been focused on as a significant contributor to the leakage of fibrin and/or fibrinoid material into the Bowman's space, thereby accelerating crescent formation in various types of glomerular disease 1. We would like to show our serendipitous finding of a break in the GBM discovered during routine diagnostic transmission electron microscopy in a 52-year-old male patient presenting with Churg-Strauss syndrome (CSS). He was admitted to our hospital due to a protracted fever, fatigue, and muscle pain of the extremities that had lasted 2 months. More than two decades prior to admission, he was found to have bronchial asthma, for which he had received sporadic medical care including the administration of montelukast, a leukotriene receptor antagonist (LTRA).