Green synthesis and antibacterial activity of 3-(3-aryl1,8naphthyridin-2-yl)-7-1-1,4-dioxo-1,2,3,4-tetrahydro-6-phthalazinyl-2,2,2-trifluoro-1-(trifluoromethyl)ethyl-2-(3-aryl 1,8naphthyridin-2-yl)-1,2,3,4-tetrahydro-1,4-phthalazinediones

摘要

A simple and highly efficient procedure has been described for the synthesis of 3-(3-aryl1,8naphthyridin-2-yl)-7-1-1,4-dioxo-1, 2, 3, 4-tetrahydro-6-phthalazinyl-2, 2, 2-trifluoro-1-(trifluoromethyl)ethyl-2-(3-aryl1,8naphthyridin-2-yl)-1,2,3,4-tetrahydro-1,4-phthalazinediones 3 by the condensation of 3-aryl-2-hydrazino-1,8-naphthyridines 1 with 4,4 '-(hexafluoroisopropylidene)diphthalic anhydride 2 in 2:1 molar ratio in the presence of catalytic amount of DMF under microwave irradiation/ in presence of catalytic amount of PTSA in the solid state at RT under grinding conditions. The products have been obtained in very good yields and in a state of high purity. The structures of the compounds 3 have been established on the basis of their spectral (IR and H-1 NMR) and analytical data. The compounds 3 have been screened for their antibacterial activity.