Utility of gold nanoparticles/silica modified electrode for rapid selective determination of mebeverine in micellar medium: comparative discussion and application in human serum

摘要

A novel electrochemical sensor for the selective determination of mebeverine hydrochloride (MEB) in drug substance, products, and human plasma was introduced. The prepared nanoparticle sensor was based on a carbon paste electrode chemically modified with silica and gold nanoparticles. The surface morphology of the modified electrode was characterized by scanning electron microscope. Several parameters such as pH, scan rate, and accumulation time were optimized in order to determine the best conditions for analysis. A good linear response was obtained in the range of 4.0 x 10(-8)-1 x 10(-5) mol L-1 with detection limit of 1.5 x 10(-9) mol L-1. The obtained results are in good agreement with those obtained by official method. The method was applied for determination of mebeverine hydrochloride in different pharmaceutical dosage forms containing MEB alone or in mixtures with sulpiride or chlordiazepoxide as well as in human plasma. The developed method was simple, rapid, economic, and challenging to green chemistry.