Brain event-related potentials associated with psychiatric symptoms in amphetamine-type stimulant dependent patients

摘要

Objective: To explore the correlation between brain event-related potentials (ERPs) and psychiatric symptoms in patients with amphetamine-type stimulants (ATS) dependence. Method: Using Galileo Sirius 32-channels digital-evoked potential system, we measured the auditory P300 ERP in 40 ATS dependence subjects and 30 normal controls, respectively. Symptom Checklist 90 (SCL-90) was used to rate the psychiatric symptoms in the subjects. Results: In ATS dependence subjects, the latency of N 2, latency of P 2, and inter-peak latency of P 2-N 2 were significantly longer than those in controls, respectively (P 0.05). The amplitude of P300 in ATS dependence subjects was significantly lower than that in controls (P 0.01). Besides, significantly lower amplitude of P 2 and longer latency of P 2 were found in ATS dependence subjects suffering from psychiatric symptoms than those without psychotic symptoms (P 0.05). Furthermore, in ATS dependence subjects, the latency of N 2 was negatively correlated with the scores of anxiety factor (r = -0.366) and paranoid ideation factor of SCL-90; the latency of P 2 negatively correlated with the scores of psychoticism (r = -0.430) and somatization (r = -0.397) factor; also, the amplitude of P 2 was negatively correlated with the score of psychoticism factor (r = -0.486). Conclusions: These findings suggest cognitive dysfunction may be one of results of ATS dependence.