Synthesis of tricyclic systems containing a fused thieno3,4-dpyrimidine nucleus

El-Telbany F.A.; El Hakeem M.A.; Khalil O.M.Mikhail D.S.

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Synthesis of tricyclic systems containing a fused thieno3,4-dpyrimidine nucleus

机译：含有稠合噻吩并3,4-d嘧啶核的三环系统的合成

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摘要

The synthesis and characterisation of novel tricyclic systems containing a fused thieno3,4-dpyrimidine nucleus starting from a useful synthon, ethyl-4-cyano-3-ethoxymethyleneamino-5-phenylamino-2-thiophenecarboxylate, are reported.

机译：报道了含有从有用的合成子乙基-4-氰基-3-乙氧基亚甲基氨基-5-苯基氨基-2-噻吩羧酸酯开始的稠合噻吩并[3,4-d]嘧啶核的新型三环系统的合成和表征。

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《Journal of chemical research: reviews and research papers from all branches of chemistry》 |2012年第8期|480-483|共4页
作者
El-Telbany F.A.; El Hakeem M.A.; Khalil O.M.Mikhail D.S.;
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作者单位

Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt;

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原文格式 PDF
正文语种英语
中图分类化学;
关键词
Aminothiophene-2-carboxylates; Dimroth rearrangement; Imidate; Thieno3; 4-dpyrimidine; Tricyclic heterocycle;

机译：氨基噻吩-2-羧酸酯;Dimroth 重排;亚撽酸盐;蒂耶诺[3;4-d]嘧啶;三环杂环;

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专利

1. Design, synthesis, biological evaluation and X-ray crystal structure of novel classical 6,5,6-tricyclic benzo(4,5)thieno(2,3-d)pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors. [J] . Zhang X, Zhou X, Kisliuk RLPiraino JCody VGangjee A Bioorganic and medicinal chemistry . 2011,第11期

机译：Design, synthesis, biological evaluation and X-ray crystal structure of novel classical 6,5,6-tricyclic benzo(4,5)thieno(2,3-d)pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors.
2. ChemInform Abstract: Azoles. Part 12. Synthesis of Thieno‐Extended Purines: First Example of the Imidazo(4′,5′:4,5)thieno(3,2‐d)pyrimidine Ring System. [J] . D. W. HAWKINS, B. IDDON, D. S. LONGTHORNE Chem Inform . 1996,第12期

机译：ChemInform Abstract: Azoles. Part 12. Synthesis of Thieno‐Extended Purines: First Example of the Imidazo(4′,5′:4,5)thieno(3,2‐d)pyrimidine Ring System.
3. Synthesis and antiviral evaluation of thieno(3,4-d)pyrimidine C-nucleoside analogues of 2',3'-dideoxy- and 2',3'-dideoxy-2',3'-didehydro-adenosine and -inosine. [J] . Hamann M, Pierra C, Sommadossi JPMusiu CVargiu LLiuzzi MStorer RGosselin G Bioorganic and medicinal chemistry . 2009,第6期

机译：Synthesis and antiviral evaluation of thieno(3,4-d)pyrimidine C-nucleoside analogues of 2',3'-dideoxy- and 2',3'-dideoxy-2',3'-didehydro-adenosine and -inosine.
4. Study on Synthesis of 6-Pentyl-tetrahydro-thieno 3,4-dimidazol-2-one [C] . Cheng Liang, Shuanglin Qin, Shuangping Huang, International Conference on Machinery, Materials Engineering, Chemical Engineering and Biotechnology . 2016

机译：6-戊基 - 四氢-Thieno合成的研究3,4-D咪唑-2-一体化
5. Synthesis, clathrate inclusion properties and racemization studies of Benzo-fused tetraphenylenes. [O] . 1988

机译：synthesis, clathrate inclusion properties and racemization studies of Benzo-fused tetraphenylenes.

Synthesis of tricyclic systems containing a fused thieno3,4-dpyrimidine nucleus

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