COPPER(II) BINARY COMPLEX EQUILIBRIA, WITH [S]- AND [R]-2-BENZYLAMINO-METHYLPYRROLIDINES UNDER PHYSIOLOGICAL CONDITIONS

摘要

Among a series of newly synthesised chiral aminomethylpyrrolidines, the 2-benzyl-substituted derivative was recently recognised as a possible precursor of copper(II) ligands with (.) OH-scavenging properties, In a preliminary attempt to characterise the structure of the copper(II) complexes of this type of ligand, formation complex equilibria of the copper(II) ion with the [S] and [R] enantiomers of the parent 2-benzylaminomethylpyrrolidine have been investigated at 37 degrees C in 0.15 mol dm(-3) NaClO4 using glass electrode potentiometry, UV-Vis spectrophotometry and circular dichroism. Two main complexes have been found, ML and ML(2), with appreciable stabilities compared to their copper(II) homologues of histidine, the predominant low-molar-mass ligand of copper(II) in blood plasma. These species are also characterised by clear Cotton effects. Possible structures are discussed. [References: 29]