Benzylamidine complexes of platinum(II) derived by nucleophilic addition of primary and secondary amines. X-ray crystal structure of trans-[ PtCl2{Z-N(H)=C(NHMe)CH2Ph}(2)]

摘要

The reaction of cis- and trans-[PtCl2(NCCH2Ph)(2)] with a 5-fold excess of MeNH2 and Me2NH in CH2Cl2 at -10 degrees C affords in high yield the bis-amidine derivatives cis- and trans-[PtCl2{Z-N(H)=C(NHMe)CH2Ph}(2)] (1a, 2a) and cis- and trans-[PtCl2{EN(H)=C(NMe2)CH2Ph}(2)] (3a, 4a), respectively. The complexes were characterized by means of elemental analysis, multinuclear NMR and FT-IR techniques. The X-ray diffraction analysis was carried out for trans-[PtCl2{Z-N(H)=C(NHMe)CH2Ph}(2)] (2a). Moreover, the in vitro cytotoxicity for the new derivatives was evaluated in a wide panel of human tumor cell lines. (c) 2008 Elsevier B.V. All rights reserved.