Interaction of Fe(III) with herbicide-carboxylato ligands. Di-, tri- and tetra-nuclear compounds: Structure, antimicrobial study and DNA interaction

摘要

The iron complexes with the phenoxyalkanoic acids 2,3-D = 2,3-dichlorophenoxyacetic acid, 3,4-D = 3,4-dichlorophenoxyacetic acid, 2,4,5-T = 2,4,5-trichlorophenoxyacetic acid, and mcpa = 2-chloro-4-methyl-phenoxyacetic acid, in the presence or not of a nitrogen donor heterocyclic ligand, py = pyridine, bipy = 2,2' bipyridine, phen = 1,10-phenanthroline, were prepared and characterized. The interaction of Fe(III) with phenoxyalkanoic acids and bipy or phen leads to dinuclear neutral complexes, while the presence of py favors tetranuclear neutral forms. The crystal structures of [Fe2OCl2(mcpa)(2)(bipy)(2)] center dot 0.25(bipy) center dot 0.8MeCN (la), and {[Fe4O2(mcpa)(6)Cl-2(py)(4)] center dot 2MeCN} (3a), have been determined. DNA-Fe(III) complex interaction studies suggest that iron complexes promote the hydrolytic cleavage of double stranded DNA that seems to be oxygen independent, while pDNA shows cross-linking with many molecules of the iron clusters. Antibacterial screening data showed that the presence of chelating agents, bipy or phen, increased the efficiency of iron complexes. (c) 2006 Elsevier B.V. All rights reserved.