METAL-DRUG INTERACTIONS - SYNTHESIS AND CRYSTAL STRUCTURE OF DICHLORODITHIABENDAZOLECOBALT(II) MONOHYDRATE

摘要

The crystal structure of dichlorodithiabendazolecobalt(II) monohydrate [CoCl2(C10H7N3S)(2) . H2O] has been determined from X-ray diffraction data using Mo K alpha radiation. The crystals are monoclinic, P2(1)/c with a=15.328(5), b=11.2131(8), c=13.967(5) Angstrom, beta=114.27(1)degrees and Z=4. The structure was solved and refined to a final R value of 0.0332 with 3717 observed reflections. Two chlorine atoms and two thiabendazole ligands form an octahedral geometry around cobalt. Each thiabendazole, [2-(4-thiazolyl)-1H-benzimidazole], is bidendate chelating and is bonded to cobalt through the nitrogen atoms of the thiazolyl and benzimidazole rings in cis configuration. The protonated nitrogen atom of the imidazole ring is trans to the thiazole nitrogen atom. [References: 11]