Neoatherosclerosis: a novel player in late stent failure

摘要

Evidence derived from histopathologic and intravascular imaging studies has suggested a key role for neoatherosclerosis as a substrate for the occurrence of late events after both drug-eluting stent and bare-metal stent implantation. In particular, the development of neoatherosclerosis has been associated with occurrence of late in-stent restenosis and stent thrombosis. In this review, we describe pathogenetic mechanisms responsible for neoatherosclerosis and recent evidences deriving from histopathologic and intravascular imaging studies. Finally, we discuss possible approaches for risk stratification and therapeutic strategies.