Synthesis and spectral determination of new derivatives of 1-(p-substituted)phenyl-3a-(o- and p-substituted)phenyl-5-chloro-9-methylthio-10,3a-dihydro-1,2,4-oxadiazolo2,3-b1,4benzodiazepines

摘要

A new synthesis to obtain eight novel derivatives of 1-(p-substituted)phenyl-3a-(o- and p-substituted)phenyl-5-chloi-o-9-methylthio-10,3a-dihydro-1,2,4-oxadiazolo2,3-b1,4benzodiazepines with possible biological and pharmacological activity as anxiolytics, hypnotics, anticonvulsants in the central nervous system. The final products were obtained by condensation between 2-methylthio-5-(o-; p-substituted)phenyl-3H-7-chloro-1,4benzodiazepine with benzonitrile oxide generated in situ from benzohydroxamoyl chloride in triethylamine. The structure of all products was corroborated by ir, H-1-nmr, C-13-nmr, with experiments bidimensional and ms in low and high resolution.