BOVINE LEUCOCYTE ADHESION DEFICIENCY (BLAD) IN A ONE YEAR OLD HOLSTEIN FRIESIAN BULL--THE FIRST REPORT IN THE UNITED KINGDOM

摘要

Bovine leucocyte adhesion deficiency (BLAD) is a condition reported in the Holstein breed, and appears to have an autosomal recessive pattern of inheritance (Kehrli et al., 1992). It is characterized by deficiency of the Mac-l(CDllb/CD18) cell-surfacereceptor of the integrin family (Kehrli et al, 1990). A wide range of leucocyte functions, which are involved in normal host defences to infection, are dependent on cell surface adherence reactions, and their absence impairs the ability of cattle to counteract infection. Affected calves tend to die when 2-7 months old (McVey & Tizard, 1993), usually of enteritis or pneumonia of infectious origin apparently due to dysfunctioning inflammatory leucocytes. We report here our clinical findings on a confirmed case of BLAD believed to be the first recorded in the United Kingdom.