The Role of Lipid Lowering Therapy in the Achievement of Therapeutic Goal among Malaysian Hyperlipidemic Patients

摘要

Objectives: This study is aimed to measure the LDL-C achievement in response to lipid lowering therapy and to demonstrate the lipid profile parameters of Malaysian dyslipidemic patients in comparison to Malaysian healthy populations. Design: retrospective record review analysis was conducted.Materials and Methods: 980 dyslipidemic files were obtained from the Record Unit, Hospital Universiti Sains Malaysia (HUSM), in the State of Kelantan, Malaysia. The dyslipidemic patients included were those with prescribed lipid lowering therapy, standard statin dose or otherwise, from January 2007 (index date).The first lipid profile parameters value reading before starting the lipid lowering therapy was regarded as a baseline.Results: Statins were prescribed in 92.2%. Atorvastatin was prescribed in 50% of the patients. Those on losvastatins were obtained the best LDL-C achievement (48.4 %) with a significant difference among the different drugs groups (P = 0.04). There was a significant difference in the lipid profiles between the dyslipidemic patients in this study and the healthy populations from other studies (P < 0.0001, < 0.0001, 0.01, < 0.0001) for total cholesterol, low density lipoprotein cholesterol, high density lipopro-tein cholesterol and triglyceride level, respectively.Conclusion: The majority of the dyslipidemic patients were on statins with the biggest response among those who are on losvastatins. The lipid profile parameters of Malaysian dyslipidemic patients were significantly higher than those from that healthy population.