Quantitative Analysis of Hemodynamics in Bruised Skin Using Photothermal Depth Profiling

摘要

Pulsed photothermal radiometry (PPTR) allows noninvasive measurement of laser-induced temperature depth profiles, providing useful information on depth distribution of specific absorbers in optically scattering biological tissues. In the present study, PPTR profiling is combined with numerical modeling of light transport in human skin to analyze hemoglobin dynamics in traumatic bruises. Specifically, the influence of regularization degree, applied in iterative reconstruction of temperature depth profiles from PPTR signals measured in bruised volunteers, is studied. The results show that selection between two plausible reconstruction results does not significantly affect the assessed values of key bruise evolution parameters, i.e., hemoglobin mass diffusion and characteristic decomposition time.