Preparation of novel chitosan-containing micro- and nanofibrous materials by electrospinning

摘要

Electrospinning is an efficient and versatile technique for fabrication of nanofibres. This article presents a condensedoverview of this technique, with emphasis on chitosan-based nanofibrous materials. For the first time two easilyfeasible and efficient approaches for preparation of micro- and nanofibrous materials containing the natural polymerchitosan were proposed. The first approach relied upon electrospinning of chitosan and a non-ionogenic polymer mixedsolutions. The mean diameters of the nanofibres were in the range of 40-290 nm. The second approach consisted ofcoating of electrospun poly(L-lactide) or poly(L-lactide)/poly(ethylene glycol) nanofibrous mats with chitosan.Particular potential applications of these novel materials in the biomedical field such as drug delivery systems andwound dressings were evaluated.