Successful treatment of recurrent and refractory cervical condylomata acuminata with topical 5% imiquimod cream in five patients.

摘要

Sirs: Five percent imiquimod cream is a topically active immu-nomodulatory agent proven to be effective in the treatment of genital warts, but rarely used to treat cervical condylomata acu-minata (CA). Here we report five women aged 21-40 years suffering from recurrent and refractory cervical CA. They had received previous treatment of CO2 laser or electrocautery 2-4 times during the past 1-6 months. After physical examination and the acetic acid test, we found pale or pink plaques on the cervix uteri, which were grossly cauliflower-like or asperous, and acetowhitening lesions. We diagnosed these patients clinically as having recurrent CA on the cervix uteri. After the patients signed informed consents in the first visit, a piece of the lesion was clamped out for biopsy, and then high-frequency electrocautery therapy was given (Figure la and b). As soon as the ulcers healed one to two weeks later, and we had made sure of the diagnosis of cervical CA by the biopsy and immuno-chemical staining for human papillomavirus antigen (HPV-Ag), we applied 5% imiquimod cream to the cervix uteri (Figure lc).