We are pleased to present this special issue of the International Journal of Radiation Oncology Biology Physics, dedicated to the Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC). This work is the result of the diligent efforts of numerous investigators, authors, reviewers, and support personnel. We are particularly indebted to the comembers of the QUANTEC Steering Committee1, for their dedication.This is an exciting time in the field of radiation oncology. Sophisticated treatment-planning tools and delivery systems remarkably increase our ability to steer the dose where we want it. An increased knowledge of how dose distributions affect normal tissue outcomes is critically needed to know how best to exploit these new planning/delivery tools. In 1991, Emami et al.
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