Eight year follow-up of an epidemic of sirenomelia in Cali, Colombia

摘要

The ECLAMC (Latin-American Collaborative Study of Congenital Malformations) network, reported the unusual occurrence of four sirenomelia and four cyclopia cases of born in the city of Cali, Colombia in 2005, statistically suggesting an epidemic [Castilla et al., 2008]. The follow-up to 2013, showed four new cases born in Cali in the 2006-2013 period among 483,524 births, with a prevalence of 0.83 per 100,000, significantly (P = 0.001) lower than the intra-epidemic rate (1.954), and similar to the ECLAMC baseline value for the pre-epidemic period 1982-2003:0.225 per 100,000 (P= 0.123). Pvalues by exact Poisson test.