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首页> 外文期刊>Inflammation >Effects of Baicalin and Octreotide on the serum TNF-alpha level and apoptosis in multiple organs of rats with severe acute pancreatitis.
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Effects of Baicalin and Octreotide on the serum TNF-alpha level and apoptosis in multiple organs of rats with severe acute pancreatitis.

机译：黄ical苷和奥曲肽对重症急性胰腺炎大鼠血清TNF-α水平及多器官细胞凋亡的影响。

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We investigated the effects of Baicalin and Octreotide on the levels of endotoxin and TNF-alpha in blood and the effects of apoptotic changes in multiple organs of SAP rats, and explored the underlying therapeutic mechanisms of Baicalin and Octreotide. In this study, 135 SAP rats were randomly divided into model control, Baicalin treated and Octreotide treated group (n = 45), respectively, the same number of normal rats were included in sham-operated group (n = 45). The above-mentioned groups were further subdivided into 3, 6 and 12 h subgroups, respectively (15 rats in each subgroup). At 3, 6 and 12 h after operation, the mortality rate of rats, endotoxin and TNF-alpha levels in blood as well as the pathological severity scores, expression levels of Bax protein and apoptosis indexes in multiple organs were determined. Compared to model control group (1),both drugs can relieve the pathological injuries of multiple organs and decrease significantly the levels of endotoxin and TNF-alpha in blood and the mortality rate of rats in treated groups (P < 0.05 or P < 0.01); (2) the expression of Bax protein was upregulated in pancreas, lung, intestinal mucosa (P < 0.05 or P < 0.01) but downregulated in spleen and lymph nodes (P < 0.001 and P < 0.05, respectively) in Baicalin treated group; The apoptosis indexes significantly increased in pancreas, intestinal mucosa, lymph nodes and spleen (P < 0.05 or P < 0.01). (3) the expression of Bax protein was upregulated in pancreas and lung but downregulated in spleen and lymph nodes (P < 0.05 or P < 0.01) in Octreotide treated group; The apoptosis indexes significantly increased in lymph nodes and spleen in Octreotide treated group (P < 0.05 or P < 0.01). Baicalin and Octreotide share a similar therapeutic efficacy in the treatment of SAP via a mechanism that is associated with inhibiting the levels of TNF-alpha in blood and induce apoptosis in multiple organs.
机译：我们研究了黄ical苷和奥曲肽对血液中内毒素和TNF-α水平的影响以及SAP大鼠多个器官凋亡变化的影响，并探讨了黄ical苷和奥曲肽的潜在治疗机制。在这项研究中，将135只SAP大鼠随机分为模型对照组，黄ical苷治疗组和奥曲肽治疗组（n = 45），假手术组（n = 45）包括相同数量的正常大鼠。将上述各组进一步分为3、6和12 h亚组（每亚组15只大鼠）。分别于术后3、6、12 h，测定大鼠的死亡率，血液中的内毒素和TNF-α水平，以及多个器官的病理学严重程度评分，Bax蛋白表达水平和细胞凋亡指数。与模型对照组（1）相比，这两种药物均可减轻多器官的病理损伤，并显着降低治疗组的血液中内毒素和TNF-α的水平以及大鼠的死亡率（P <0.05或P <0.01） ; （2）在黄ical苷治疗组中，胰腺，肺，肠粘膜中Bax蛋白的表达上调（P <0.05或P <0.01），而在脾脏和淋巴结中Bax的表达下调（分别为P <0.001和P <0.05）;胰腺，肠粘膜，淋巴结和脾脏中的凋亡指数显着增加（P <0.05或P <0.01）。 （3）奥曲肽治疗组胰腺和肺中Bax蛋白表达上调，但在脾和淋巴结中Bax蛋白表达下调（P <0.05或P <0.01）。奥曲肽治疗组的淋巴结和脾脏中的凋亡指数显着增加（P <0.05或P <0.01）。黄ical苷和奥曲肽通过与抑制血液中TNF-α水平并诱导多个器官凋亡相关的机制在SAP的治疗中具有相似的治疗功效。

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