Linkage disequilibrium between IRF6 variants and nonsyndromic cleft lip/palate in the Chilean population.

摘要

The genetics of nonsyndromic cleft lip and palate (NSCLP) is complex. Several candidate genes have been associated with this phenotype, but replication studies showed conflicting results [Carinci et al., 2000; Murray, 2002]. Candidate gene analyses indicate that variants in a handful of genes taken together may account for approximately 15-20% of the genetic contribution to NSCLP [Zucchero et al., 2004; Vieira et al., 2005; Riley et al., 2007].