Fabrication and In Vitro Bioactivity of Poly (ε-caprolactone) Composites Filled with Silane-Modified Nano-Apatite Particles

摘要

Silane coupling agents were firstly employed to modify the surfaces of nano-apatite (n-HA) particles, and then thin films of the silanized n-HA/PCL composites were successfully developed by incorporating solvent dispersion and thermal co-blending with hot-pressing methods. In vitro studies were conducted using the 2-time simulated body fluid (2SBF). Composite specimens were soaked in 2SBF from 3 to 14. Results showed that a layer of bone-like apatite was formed within 7 days on the surfaces of all composites, after its immersion in 2SBF, demonstrating moderate in vitro bioactivity of these composites.