首页> 外文期刊>Infectious diseases in obstetrics and gynecology >Detection of fastidious vaginal bacteria in women with HIV infection and bacterial vaginosis.
【24h】

Detection of fastidious vaginal bacteria in women with HIV infection and bacterial vaginosis.

机译:检测感染HIV和细菌性阴道病的女性的挑剔阴道细菌。

获取原文
获取原文并翻译 | 示例
           

摘要

BACKGROUND: Fastidious bacteria have been associated with bacterial vaginosis (BV) using PCR methods. We assessed the prevalence of these bacteria in HIV-1 infected women and their relationship with vaginal pH and shedding of HIV-1 RNA. METHODS: 64 cervicovaginal lavage (CVL) samples were collected from 51 women. Vaginal microbiota were characterized using 8 bacterium-specific quantitative PCR assays. RESULTS: Women with the fastidious bacteria Bacterial Vaginosis Associated Bacterium (BVAB) 1, 2, and 3 showed a trend to increased HIV-1 shedding (OR 2.59-3.07, P = .14-.17). Absence of Lactobacillus crispatus (P < .005) and presence of BVAB2 (P < .001) were associated with elevated vaginal pH. BVAB1, 2, and 3 were highly specific indicators of BV in HIV-infected women, with specificities of 89%-93%. CONCLUSIONS: Fastidious bacteria (BVAB 1, 2, and 3) remain specific indicators of BV in HIV-infected women, and BVAB2 may contribute to the elevated vaginal pH that is a hallmark of this syndrome.
机译:背景:使用PCR方法,耐细菌已经与细菌性阴道病(BV)相关。我们评估了这些细菌在感染HIV-1的女性中的患病率及其与阴道pH和HIV-1 RNA脱落的关系。方法:从51名妇女中收集了64份宫颈阴道灌洗液(CVL)样本。阴道微生物群使用8种细菌特异性定量PCR分析进行了表征。结果:患有细菌性细菌性阴道病相关细菌(BVAB)1、2和3的妇女表现出增加HIV-1脱落的趋势(OR 2.59-3.07,P = .14-.17)。缺乏乳杆菌(P <.005)和BVAB2(P <.001)与阴道pH升高有关。 BVAB1、2和3是HIV感染妇女中BV的高度特异性指标,特异性为89%-93%。结论:挑食性细菌(BVAB 1、2和3)仍然是感染HIV的女性BV的特定指标,BVAB2可能导致阴道pH升高,这是该综合征的标志。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号