Bioartificial polymer materials based on pvcatural polymer blends:Binary pvc/hydrolyzed collagen blends

摘要

Compatibility and biocompatibility of the binary blends of plasticized poly(vinyl chloride)and hydrolyzed collagen have been studied.The following investigation methods have been used:differential scanning calorimetry,thermogravimetry,contact angle measurements,and to assess the biocompatibility,"in vitro" cell growth test.The results indicate that these materials behave as relatively homo?geneous systems and that the surface polarity increases by collagen incorporation.Polyvinyl chloride interacts with hydrolyzed collagen through either hydrogen or chemical bonds.A better substrate for cell growth in comparison with pure components has been obtained.The main effects of the combination of these polymers are,on the one hand,the improvement of hydrophylicity and thermal stability of PVC,and on the other hand,the rapid dissolution is avoided of the collagen-based materials when in contact with biological fluids,which means a better biological stability in terms of resistance to enzymatic digestion.