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首页> 外文期刊>International Journal of Pharmaceutics >Effect of expansion chamber geometry on atomization and spray dispersion characters of a flashing mixture containing inerts. Part I. Numerical predictions and dual laser measurements
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Effect of expansion chamber geometry on atomization and spray dispersion characters of a flashing mixture containing inerts. Part I. Numerical predictions and dual laser measurements

机译:膨胀室几何形状对含有惰性物质的闪蒸混合物的雾化和喷雾分散特性的影响。第一部分:数值预测和双激光测量

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A cigarette alternative is designed to deliver a dose of medicinal nicotine within a timeframe comparable to that of a cigarette, and gives much of what smokers expect from a cigarette without the risks of smoking tobacco. The design concept is the same as a pressurized metered dose inhaler (pMDI), but is a breath actuated device (Oxette?). This work predicts the residual mass median diameter (MMD) of the spray issuing from early stage Oxette? prototypes by using an evaporation model of multi-component liquid droplets with the help of a numerical multi-component two-phase actuation model (developed by the authors) to quantify the sprays. Two different formulations with 95% and 98% mass fraction of HFA 134a, and two prototypes of cigarette alternatives with different expansion chamber volumes have been analyzed by the numerical model and compared with laser based measurements. The later designed device provides a larger expansion chamber volume to enhance the propellant evaporation, recirculation, bubble generation and growth inside the chamber, and it makes a significant improvement to produce finer sprays than the earlier design. The mass fraction of the formulation does not affect significantly on the initial MMD of the droplets near the discharge orifice. However, it influences the residual MMD at x = 100 mm from the discharge orifice, where the ratio of the predicted residual MMDs of the droplets generated by the formulations with 98% and 95% of HFA 134a is 0.73. Although the formulation with 98% of HFA 134a can generate smaller droplets, the formulation with 95% of HFA 134a produces more steady puffs with relatively low mass flow rate.
机译:卷烟替代品旨在在与卷烟相当的时间范围内提供一定剂量的尼古丁,并提供吸烟者对卷烟的期望值,而没有吸烟的风险。设计概念与加压定量吸入器(pMDI)相同,但是是一种呼吸致动装置(Oxette?)。这项工作可预测早期Oxette?产生的喷雾残留质量中值直径(MMD)。通过使用多组分液滴的蒸发模型和数字多组分两相驱动模型(由作者开发)的帮助来对喷雾进行量化。通过数值模型分析了两种具有95%和98%质量分数的HFA 134a的不同配方,以及两种具有不同膨胀室容积的卷烟替代品的原型,并与基于激光的测量结果进行了比较。后来设计的装置提供了更大的膨胀室容积,以增强推进剂在燃烧室内的蒸发,再循环,气泡的产生和增长,并且与早期设计相比,在产生更细的喷雾剂方面进行了重大改进。制剂的质量分数对排放孔附近的液滴的初始MMD没有显着影响。但是,它会影响距排放孔x = 100 mm处的残留MMD,此时,由含98%和95%的HFA 134a的配方产生的液滴的预计残留MMD的比率为0.73。尽管具有98%的HFA 134a的制剂可产生较小的液滴,但具有95%的HFA 134a的制剂可产生质量相对较低的更稳定的粉扑。

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