首页> 外文期刊>International Journal of Pharmaceutics >In vitro cytotoxicity and drug release properties of pH- and temperature-sensitive core-shell hydrogel microspheres.
【24h】

In vitro cytotoxicity and drug release properties of pH- and temperature-sensitive core-shell hydrogel microspheres.

机译:pH和温度敏感的核壳水凝胶微球的体外细胞毒性和药物释放特性。

获取原文
获取原文并翻译 | 示例
       

摘要

A simple method has been developed to prepare smart P(N,N-diethylacrylamide-co-methacrylic acid) (P(DEA-co-MAA)) microspheres that consist of well-defined temperature-sensitive cores and pH sensitive shells. The microgels have been prepared by surfactant-free emulsion polymerization using water as the solvent. The core-shell hydrogel microspheres have been characterized by Fourier transform infrared (FTIR) spectroscopy, UV spectrometry, dynamic light scattering (DLS) and transmission electron micrograph (TEM). Preliminary characterization of the biocompatibility of hydrogel microspheres has been done by the cytotoxicity assays using the HeLa human breast cancer cell line as probes. The in vitro drug release indicates that drug release rate, encapsulation efficiency (EE) and release kinetics depend upon the pH value and copolymer composition. According to this study, the hydrogel microspheres based on P(DEA-co-MAA) could serve as suitable candidate for drug site-specific carrier in intestine.
机译:已开发出一种简单的方法来制备智能P(N,N-二乙基丙烯酰胺-共-甲基丙烯酸)(P(DEA-co-MAA))微球,该微球由定义明确的温度敏感核和pH敏感壳组成。通过使用水作为溶剂通过无表面活性剂的乳液聚合来制备微凝胶。核-壳水凝胶微球已通过傅里叶变换红外(FTIR)光谱,紫外光谱,动态光散射(DLS)和透射电子显微照片(TEM)进行了表征。水凝胶微球的生物相容性的初步表征已通过使用HeLa人乳腺癌细胞系作为探针的细胞毒性试验完成。体外药物释放表明药物释放速率,包封效率(EE)和释放动力学取决于pH值和共聚物组成。根据这项研究,基于P(DEA-co-MAA)的水凝胶微球可作为肠道中药物位点特异性载体的合适候选者。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号