SIMULTANEOUS DETERMINATION OF TRACE ELEMENTS IN SERA OF PATIENTS WITH ACUTE MYOCARDIAL INFARCTION BY PIXE -2-

摘要

Vascular cell adhesion molecule-1 (VCAM-1) is transiently expressed on vascular endothehal cells in response to cytokines. It plays a major role in the adhesion of leucocytes to the endothelium by interaction with its ligand VLA-4, a member ofthe ? 1 integrin family. We measured the serum concentration of the soluble VCAM-1 (sVCAM-1) in 114 patients with acute myocardial infarction (AMI) and 37 normal controls by enzyme-linked unmunoassay m comparison with trace element concentraUon. sVCAM-1 levels were markedly higher (mean ± SD - 833.2 ± 328.9 ng/ml) in the sera of patients with AMI than in normal controls (P 549.5 ± 188.8 ng/ml, p<0.001). Using PIXE we also determined concentrator, ot manganese, iron, copper, zinc, selenium, and calcium in sera of 43 patients with were no clear correlation between the sVCAM-1 concentration and e lagnesmm, manganese copper, selenium, iron. But there were significant correlation between the sVCAM concentration and the zinc, calcium (p<0.05).