Commentary feedback from African palliative care practitioners on the use of the APCA POS

摘要

Objective: To determine the role of vitamin D for preventing or reducing postoperative adhesions. Study Design: The uterine horn adhesion model was carried out in 24 female Wistar rats. The animals were randomized into 4 groups: (1) control, (2) Ringer's lactate, (3) olive oil, and (4) vitamin D. Adhesion grade and histologic findings of adhesion-carrying tissues were evaluated, and groups were compared according to these parameters. Results: Rats treated with vitamin D had less adhesion and lower inflammation grade when compared to the control and Ringer's lactate groups, and the results were statistically significant (p<0.05). On the other hand, no difference was detected between the groups according to the fibrosis score. Conclusion: Vitamin D decreased postsurgical adhesion scores by both visual scores and histologic analyses in a rat model. Further experimental and clinical trials are required to confirm these results.