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High-intensity focused ultrasound ablation: An effective and safe treatment for secondary hypersplenism

机译:高强度聚焦超声消融:继发性脾功能亢进的安全有效治疗

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Objective: Hypersplenism is a common disease. The conventional treatment is splenectomy and partial splenic embolization; however, both of them have high complication rates and technical defects. Therefore, safer and more effective techniques should be considered for the treatment of hypersplenism. High-intensity focused ultrasound (HIFU) may provide an effective and safe way for treatment of hypersplenism. Therefore, we conducted this study to assess the safety and efficacy of HIFU in treatment of secondary hypersplenism.Methods: A total of 28 patients who suffered from secondary hypersplenism were treated with HIFU ablation. All patients who underwent HIFU were closely followedup over a year. MRI scan was performed, and the spleens were observed. Blood counts and liver function tests were also carried out.Results: In the follow-up process, the levels of white blood cells and platelets in the blood after HIFU were significantly higher than those before HIFU, liver function also improved after HIFU treatment. In addition, the symptoms were ameliorated significantly or even disappeared. The MRI showed that the ablation area had turned into a non-perfused volume, and after 12 months of HIFU ablation, the ablated area shrank evidently; the sunken spleen formed a lobulated shape and the splenic volume decreased.Conclusion: HIFU ablation is a safe, effective and noninvasive approach for secondary hypersplenism.Advances in knowledge: For the first time we used HIFU ablation to treat secondary hypersplenism. It not only expands indications of HIFU but also provides better choice for the treatment of secondary hypersplenism.
机译:目的:脾功能亢进是一种常见疾病。常规治疗是脾切除术和部分脾栓塞术。但是,它们都具有很高的并发症发生率和技术缺陷。因此,应考虑使用更安全,更有效的技术治疗脾功能亢进。高强度聚焦超声(HIFU)可能为治疗脾功能亢进提供一种有效且安全的方法。因此,我们进行了这项研究,以评估HIFU治疗继发性脾功能亢进的安全性和有效性。方法:HIFU消融治疗了28例继发性脾功能亢进的患者。所有接受HIFU治疗的患者均接受了一年以上的密切随访。进行MRI扫描,并观察到脾脏。结果:在随访过程中,HIFU治疗后血液中白细胞和血小板水平明显高于HIFU治疗前,肝功能也得到改善。此外,症状明显改善甚至消失。 MRI显示,消融区域已变成非灌注体积,HIFU消融12个月后,消融区域明显缩小。结论:HIFU消融术是继发性脾功能亢进的一种安全,有效且无创的方法。它不仅扩大了HIFU的适应症,而且为继发性脾功能亢进的治疗提供了更好的选择。

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