Side-modified 15-deoxy-Delta(12,14)-prostaglandin D-2, precursor of corresponding PGJ(2). Synthesis from cloprostenol and anticancer activity

摘要

The title compound, a possible precursor of metabolically stable corresponding PGJ(2), was obtained from cloprostenol in seven steps. The compound demonstrated cytotoxicity against the HEK 293, Hep G2 and Jurkat cell lines.