Insilico investigations of disordered regions in hypothetical sequences from human proteome as drug targets

摘要

Disordered regions of a protein are segments that lack a fixed tertiary structure and are partially folded or unfolded. Proteins with such regions participate in important regulatory functions in the cell, including transcription, translation, cell cycle and numerous signal transduction events. Human proteome, which contains about 20% of sequences annotated as 'hypothetical proteins' and consisting of disordered regions, serve as an interesting dataset for investigating the roles of disordered regions in disease associations, drag target selections, biochemical validations, determination of novel folds, etc. 离 insilico attempt has been carried out here to investigate these disordered regions in hypothetical proteins from human genome to establish their relationships with diseases and as potential drug targets.