Peptide nucleic acid - a revolutionary mimic

摘要

Peptide nucleic acids (PNAs) are oligonucleotide analogues in which the sugar-phosphate backbone has been replaced by a pseudo peptide skeleton. PNA is a chemical similar to DNA or RNA. PNA's backbone is composed of repeating N-(2-aminoethyl)-glycine units linked by peptide bonds. The various purine and pyrimidine bases are linked to the backbone by methylene carbonyl bonds. PNAs are like peptides, with the N-terminus at the left and the C-terminus at the right. Several exciting new developments in the applications of the PNA have been published recently.In this paper the PNA molecule was subjected to structural, phylogenetical and proteomics analysis using biotools such as Chemsketch, MEGA, and ProtParam etc., located in HUPO and EXPASY database and also conducted a docking process with rev gene using HEX 4.5 software.