LCRs in diseases: analysis of human hypothetical proteins

摘要

Low complexity regions (LCRs) in proteins are sequences containing regular repeats, cryptic repeats and single arnino acid repetitions, recognised by their compositional bias. These sequences are structurally disordered, and are found to participate in signalling and post-translational modifications, mediating protein-protein and protein-RNA interactions. Apart from their normal roles, LCRs are observed in diseased proteins as well. Presence of LCRs in proteins sequences also reduces the certainty to decipher their possible functions, thereby classifying them as 'hypothetical proteins'. An insilico attempt has been carried out to investigate these LCRs in hypothetical proteins from human genome to establish their relationships with diseases.