Osteoprotegerin is associated with markers of atherosclerosis and body fat mass in type 2 diabetes patients.

摘要

Osteoprotegerin (OPG) is a glycoprotein from the tumor necrosis factor receptor superfamily, involved in bone remodeling. In type 2 diabetes patients, OPG is associated with elevated coronary artery calcification score and is a predictive marker of silent ischemia. Serum OPG level has been associated with age, diabetes, hypertension, adiposity, insulin resistance and systemic atherosclerosis [1-3].In this study we aimed to determine the relationship between serum OPG level and pulse wave velocity (PWV) and NT-pro-BNP concentration as well as with other cardiovascular risk factors, including lipids, homocysteine or obesity in type 2 diabetes patients.Material included 98 consecutive patients with type 2 diabees from the diabetes outpatient clinic. Subjects with acute coronary syndrome within 3 months from examination, recent minor infection or severe illnesses were excluded. Informed consent was obtained from all subjects.In each subject we measured levels of OPG, NT-pro-BNP (by ECLIA), lipid profile, glycated hemoglobin, homocysteine and creatinine. Bone mineral density (BMD), total and visceral fat were assessed by dual-energy X-ray absorptiometry (DEXA). Carotid-femoral PWV was assessed using Complior system.