Longitudinal changes in the relationship between serum adiponectin concentration and cardiovascular risk factors among apparently healthy middle-aged adults

摘要

Cumulative evidence from experimental and clinical studies suggests that adiponectin plays a protective role in the cardiovascular system [1]. However, surprisingly, several longitudinal studies have indicated that adiponectin increased with age [2,3], and that a higher longitudinal increase in adiponectin predicted increased mortality in older persons [2,3]. Furthermore, several prospective cohort studies have also indicated that higher baseline levels of adiponectin were related with increased all-cause and cardiovascular disease (CVD) mortality, and with the severity of congestive heart failure [4,5]. Thus, the exact role of increased adiponectin production under pathophy-sioloeical conditions has not vet been fullv identified 14.51.