Brachial artery flow mediated assessment: a tool to predict the response to chronic PDE5 inhibition with tadalafil in patients with erectile dysfunction.

摘要

Impairment of cavernosal arteries responsiveness is the most common cause of erectile dysfunction (ED) whose pathogenesis primarily depends on vascular endothelial dysfunction [1]. Atherosclerotic risk factors increase the rate of ED and most male patients with angiographically documented coronary artery disease (CAD) exhibit ED [2].Endothelial injury is a basic step in the development of artherio-sclerosis and its in-vivo evaluation by brachial artery flow mediated dilatation (BAD) technique provides relevant clinical and prognostic information [3]. Phosphodiesterase 5 inhibition (PDE5i) is an effective strategy for ED improvement which improves BAD response in both ED and non-ED patients [4,5]. It is undefined whether different pre-treatment endothelial BAD patterns may predict the ED response to chronic PDE5i therapy.