Effects of the Ala379Val polymorphism of lipoprotein-associated phospholipase A2 on thrombosis and inflammation in hypertensive patients.

摘要

Lipoprotein-associated phospholipase A2 (Lp-PLA2), also known as platelet-activating acetylhydrolase (PAF-AH), has been recently proposed as an inflammatory biomarker and independent risk predictor for cardiovascular disease [ 1 ]. Moreover, several studies have demonstrated the clinical significance of several polymorphisms of the Lp-PLA2 gene for the cardiovascular system [2], The single nucleotide polymorphism (SNP) Alanine379Valine (Ala379Val) at position 379 at chromosome 6 of the gene encoding Lp-PLA2 has been shown to have an ambiguous role in the onset and development of cardiovascular diseases [3-6], However, the prevalence of the Ala379Val polymorphism on Caucasian male hypertensive patients has not been evaluated. Furthermore, correlations of this polymorphism with inflammation and thrombosis in male hypertensive patients have not been investigated. Thus, in the present study, we investigated the association of this polymorphism with arterial hypertension, inflammatory and thrombotic markers.