Antibody response achieved by different rabies prophylaxis methods. of the International Society for Infectious Diseases

摘要

The incidence of human rabies in Turkey has decreased significantly. In 2003, only one human case was reported. There is a national rabies prophylaxis guideline which is mostly based on World Health Organization and the Advisory Committee on Immunization Practices recommendations. Post-exposure treatment including cell culture vaccines and equine rabies immunoglobulin (RIG) is free of charge. Human rabies immunoglobulin (RIG) is very expensive and sometimes both types of immunoglobulin are not readily available when needed. In this study we compared the rabies antibody titers achieved by two different post-exposure prophylaxis regimens; RiG and five-dose standard vaccination versus a 2-1-1-dose vaccination schedule.