Expression of sirtuins 1, 6, tumor necrosis factor, and interferon-gamma in psoriatic patients

摘要

Sirtuins (SIRT) have been regarded as culprits in the pathogenesis of various diseases. Their exact role has not been explained. This study aimed to assess the expression of SIRT1, SIRT6, tumor necrosis factor (TNF)-alpha, and interferon (IFN)-beta in psoriatic patients. Thirty psoriatic patients and 22 controls were enrolled. Clinical examination and Psoriasis Area and Severity Index (PASI) were obtained. Two skin biopsies (lesional, peri-lesional) and one from controls were obtained. Tissue levels of SIRT1, SIRT6, TNF-alpha, and IFN-gamma were measured using ELISA. SIRT1 was significantly lower in lesional skin with gradual increase in perilesional followed by control skin (P < 0.001). SIRT6, TNF-alpha, and IFN-beta were significantly higher in lesional than perilesional and control skin (P < 0.001). Significant positive correlations were found between SIRT1 and TNF-alpha, IFN-beta and between SIRT6 and TNF-alpha in peri-lesional skin. SIRT1 and SIRT6 are potentially involved in the pathogenesis of psoriasis. Modulating their action could offer a novel therapy for such disease.