A novel HLA-DRB1 allele, HLA-DRB1*13:116, identified by sequencing-based typing in a member of the Czech National Marrow Donor Registry.

摘要

We describe the identification of a novel HLA-DRB1 allele, DRB1*13:116, in a member of the Czech National Marrow Donor Registry. The novel allele differs from the known DRB1*13:17 variant by a nucleotide exchange at position 227 (T/A) of the coding HLA-DRB1 sequence, which causes an amino acid substitution (Phe47Tyr) in the HLA-DR beta 1 chain.